Enzymatic on-site amplification:
√ Enzyme converts as much drug as its weight every minute
√ Sustained Cytotoxicity compared to decaying cytotoxicity in direct drug delivery.
Amino-acid depletion and / or cytotoxic drug production
√ Capability to simultaneously starve and poison cancer cells
Reduced off-target toxicity:
√ Enzyme loses catalytic activity due to low pH in RES macrophages
More personalized medicine:
√ Prodrug dose can be externally controlled/modulated
√ Large window of controllability due to much less toxic nature of prodrug