Oncology

Product line 1:

• Systemic enzymatic amino-acid depletion
• Asparagine depletion therapy using Asparaginase-loaded SHELS (SHELSpar)
• Against: leukemias and lymphomas
• IV or IM administered SHELS

Product line 2:

• Local enzyme-prodrug neo-adjuvant chemotherapy using enzyme-loaded SHELS
• Against: unresectable solid tumors (hepatic, lung, pancreatic, glioblastoma, etc.)
• IT administered SHELS

Product line 3:

• Systemic enzymatic amino-acid depletion + systemic chemo combination therapy
• Conventional chemotherapy + Methionine depletion using L-methioninase-loaded SHELS (methSHELS)
• Against: prostate, lung, colon, breast, pancreas, gastric, renal, GBM, etc.
• IV or IM administered SHELS (additional local component if administered IV)

Product line 4:

• Targeted enzyme-prodrug chemotherapy using enzyme-loaded SHELS
• Against: primary/metastatic solid tumors
• IV administered SHELS with active targeting ligands

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