Problems of Enzymatic Therapy

For tumor tissue selectivity, enzymes of non-human origin are needed. This results in severe problems including:


  • – Immunogenicity

– Creates intolerable immune reactions and side effects
– Immune response interferes with therapy rendering it ineffective

  • – Instability in serum
  • – Limited residence time in the body
  • – Limited tumor localization

Solution must simultaneously meet all these criteria:

1. Hide the enzymes from the immune system
2. While hidden, enzymatic activity must be maintained
3. Hiding system must be small enough for long in-vivo residence
4. Hiding system must be biologically inert and biodegradable
5. Hiding system must be targetable


DevaCell’s SHELS technology meets all

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